%38تخفیف
دانلود :بررسی هیستولوژیک و هیستومورفومتریک تأثیر کاربرد FDBA، PDFDB و Nanocrystalline hydroxyapatite silica gel در بازسازی نقائص استخوانی ایجاد شده در کالواریوم خرگوش
تعداد 109صفحه در فایل word
بررسی هیستولوژیک و هیستومورفومتریک تأثیر کاربرد FDBA، PDFDB و Nanocrystalline hydroxyapatite silica gel در بازسازی نقائص استخوانی ایجاد شده در کالواریوم خرگوش
چكيده
سابقه و هدف
بازسازی ضایعات استخوانی از اهداف ایده آل درمان های پریو دنتال و ایمپلنتهای دندانی می باشد.بیومتریالهای مختلفی به منظور دستیابی به این هدف استفاده شده و مطالعات زیادی سعی در مقایسه ومعرفی بهترین آن ها داشته است. تحقیق حاضر با هدف بررسی هیستولوژیک و هیستومورفومتریک کاربرد nanocrystalline hydroxyapatite silica gel ، FDBA و PDFDB در بازسازی نقائص استخوانی کالواریای خرگوش انجام شد.
مواد و روشها
در این مطالعه تجربی؛ چهار defect يك اندازه با قطر 8 میلیمتر در استخوان كالواريوم 16 خرگوش سفید نیوزیلندی ايجاد گردید. حفرات با استفاده از مواد پیوندی FDBA و PDFDB (CenoBone) و nanocrystalline hydroxyapatite silica gel(NanoBone) پر شده و یک حفره هم به عنوان گروه كنترل با هيچ مادهاي پر نشد. کلیه نقایص توسط غشای کلاژن (cenomembrane) پوشانده شدند 6 و 12 هفته بعد؛ حیوانات قربانی و نمونه ها تحت بررسی هیستولوژیک و هیستومورفومتریک قرار گرفتند. درصد استخوان ساخته شده و درصد ماده پیوندی باقیمانده در گروهها با آزمون آنالیز واریانس تکراری و فراوانی درجات شدت التهاب؛ نوع بافت همبند، الگوی شروع استخوانسازی و نوع استخوان با آزمون Friedman مورد قضاوت قرار گرفت.
يافتهها
بعد از 6 هفته؛ درصد استخوانسازی در گروههای FDBA؛ NanoBone؛ PDFDB و کنترل معادل 85/7±22/14؛ 91/6±57/21؛ 02/15±47/23 و 07/10±54/20 و بعد از 12 هفته؛ برابر 19/20±54/27؛ 27/6±86/23؛ 07/11±49/26 و 18/14±48/26 بوده است. تفاوت معنیداری از این جهت در گروهها در نمونههای 6 و 12 هفتهای دیده نشد.در نمونههای 6 هفتهایی تفاوتهای معنیداری از نظر فراوانی میزان التهاب در گروههای 4 گانه دیده شد (02/0p=). به گونه ای که تفاوت بین گروههای FDBA و PDFDB با گروههای کنترل و NanoBone از لحاظ آماری معنی دار بود در حالی که در نمونههای 12 هفتهایی؛ تفاوت گروههای آزمایشی و کنترل از نظر میزان التهاب معنیدار نبوده است.
نتيجهگيري
استفاده از FDBA ، PDFDB ، nanocrystalline hydroxyapatite silica gel به عنوان مواد جایگزین استخوان به طور مشابهی سبب ترمیم ضایعات استخوان کالواریوم خرگوش شدند.
كليد واژهها
نقائص استخوانی، استخوانسازی، FDBA، PDFDB، Nano-hydroxyapatite
دسته: پزشکی, علوم تجربی
برچسب: FDBA, Nano-hydroxyapatite, PDFDB, استخوانسازی, كليد واژهها نقائص استخوانی
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